- Title
- Post-operative permanent hypoparathyroidism and preoperative vitamin D prophylaxis
- Creator
- Kannan, Tara; Foster, Yasmin; Ho, David J.; Gelzinnis, Scott J.; Merakis, Michael; Wynne, Katie; Balogh, Zsolt J.; Bendinelli, Cino
- Relation
- Journal of Clinical Medicine Vol. 10, Issue 3, no. 442, p. 1-8
- Publisher Link
- http://dx.doi.org/10.3390/jcm10030442
- Publisher
- MDPI AG
- Resource Type
- journal article
- Date
- 2021
- Description
- Permanent hypoparathyroidism, a feared thyroidectomy complication, leads to significant patient morbidity, medical treatment, and monitoring. This study explores whether preoperative high-dose vitamin D loading decreases the incidence of permanent hypoparathyroidism. In a subgroup analysis, the study examines the predictive utility of day 1 parathyroid hormone (PTH) in permanent hypoparathyroidism. Patients (n = 150) were previously recruited in the VItamin D In Thyroidectomy (VIDIT) trial, a multicentre, randomised, double blind, placebo-controlled trial evaluating the role of 300,000 IU cholecalciferol administered orally a week before total thyroidectomy. Patients were contacted postoperatively beyond six months through a telephonic questionnaire. The primary outcome was permanent hypoparathyroidism, strictly defined as the need for activated vitamin D six months postoperatively. Out of 150 patients, 130 (86.7%) were contactable. Permanent hypoparathyroidism occurred in 11/130 (8.5%) patients, with a lower incidence of 5.3% (3/57) in the cholecalciferol group compared to 11% (8/73) in the placebo group; however, this was non-significant (p = 0.34). In a subgroup analysis, no relationship between day 1 PTH level and the incidence of permanent hypoparathyroidism was found (p ≥ 0.99). There was a lower rate of permanent hypoparathyroidism in the cholecalciferol group, which was not significant. The predictive utility of day 1 postoperative PTH levels may be limited to transient hypoparathyroidism.
- Subject
- permanent hypoparathyroidism; postoperative hypocalcaemia; thyroidectomy; preoperative vitamin D
- Identifier
- http://hdl.handle.net/1959.13/1473782
- Identifier
- uon:49103
- Identifier
- ISSN:2077-0383
- Language
- eng
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